Roohealthcare.com – Melanocytic nevi are skin cancers that originate in the melanocytes of the skin. While these cells normally are present in the skin of all people, there are certain conditions where these cells overgrow. In these cases, it is advisable to seek medical advice. In some cases, surgical removal of the melanocytic nevus is the best option.
Experiencing Multiple Melanocytic Nevi on the Face
A twelve-year-old female immigrant from Afghanistan presented with multiple melanocytic nevi on her face and trunk. In addition, she also had a large cerebriform melanocytic nevus on her scalp. She was otherwise healthy.
Giant melanocytic nevi may develop into papular areas of pigmentation and may be complicated by melanoma. In severe cases, the condition may result in pain, pruritus, and disfigurement. Current treatment options include surgical removal of the nevus and medical management of its associated symptoms. Unfortunately, there are no effective pharmacological treatments for the condition. However, the use of trametinib has helped patients with the symptoms of the disease.
In rare cases, malignant melanoma develops in melanocytic nevus. It is rare in childhood, but accounts for approximately 0.9% of all pediatric malignancies. In most cases, congenital melanocytic nevi are benign. They typically range from small to large in size. Small melanocytic nevi have a lower risk of developing melanoma than large ones. MPM images of melanocytic nevus show varying degrees of atypia and lentiginous hyperplasia. In two of five cases, melanocytic dendrites are visible. The MPM imaging of the melanocytic nevus shows irregular nests of nevus cells and enlarged nuclei.
Differentiating between Atypical Type and Malignant Form
During a melanocytic nevus diagnosis, it is important to distinguish between the atypical types and the malignant forms. In general, cutaneous melanocytic nevi do not require surgical treatment. However, there are some cases where conservative excision may be required. This may be necessary when the nevus is irritated by clothing or exhibits a noticeable change in color or size. Recurrence of melanocytic nevus is extremely rare, and the risk of malignant transformation is very low.
While most melanocytic nevi do not have malignant cells, they are considered to be a precursor lesions to cutaneous melanoma. Recent approaches to reduce the burden of advanced disease have focused on early detection of these moles, along with ongoing surveillance of them. Although there is no consensus as to what factors lead to the transformation of a melanocytic nevus into a melanoma, early detection of melanoma is essential to reduce the burden on the general population.
Giant congenital melanocytic nevus is a rare type of melanoma that can develop during childhood. It is estimated that seventy percent of people with giant melanocytic nevus are diagnosed by the age of 10 years. Smaller congenital melanocytic tumors can also develop into melanomas later on in life.
Most Melanocytic Nevi Appear on the Face or on the Skin
Most melanocytic nevi occur on the face or on the skin. A smaller proportion of melanocytic nevi occur in the oral cavity. Oral melanocytic nevi are rarely malignant, and are typically found on the palate or in the lip vermilion. A small proportion of these lesions are nonpigmented. The most common site for melanocytic nevi is the palate, but they can also occur in the buccal mucosa and the labial mucosa. Congenital melanocytic nevus can be asymptomatic or painful. They can be itchy and may cause overlying skin to become dry and brittle. The overlying skin can also become weaker as a result of the deep melanocyte nests.
Diagnosis of CMN can be made by clinical features and dermoscopic examination. The size and shape of the nevus can be helpful for identifying the type. It can be difficult to diagnose a smaller CMN based on its size alone. Other diagnostic criteria include the presence of hair and surface topography. The histological features of CMN are similar to common acquired nevi, although the latter tend to be more cellular and contain more cells around adnexal structures.
A MPM image of a compound nevus shows bright oval or disk-shaped cells. These cells are composed of melanocytes and pigmented basal cells. The morphology of these cells helps distinguish a melanocytic nevus from a pigmented nevus. The cells in a melanocytic nevus are usually clustered and lacking dendritic processes, making them difficult to identify as individual cells. Melanocytic naevi may form in blood vessels. They may also form in skin that is not normally pigmented. These melanocytic nevi may be present at birth or may develop as they grow in adults. If you wish to send your article to roohealthcare, you can check out this page!
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